Gervasi G B, Catalani R, Bartoli C, Carpita G, Farina C, Gelso E
Baldacci Research Laboratories, S.p.A., Pisa, Italy.
Pharmacol Res. 1995 Jun;31(6):331-6. doi: 10.1016/1043-6618(95)80085-9.
The fibrinolytic and anticoagulant activities of heparan sulphate (HS) and dermatan sulphate (DS) were compared with those of heparin using in vitro tests. Our results demonstrate that HS has higher profibrinolytic activity than heparin and DS. Although 50 times less potent than heparin in inhibiting factor IIa, HS is three times more active than DS. The action of HS resides in HCH-mediated factor IIa inhibition combined with an ATIII-mediated inhibition. DS has no action on ATIII-mediated inhibition of factor IIa. The comparison of the anticoagulant activities of the three compounds confirmed the very limited anticoagulant effect of both HS and DS in comparison with heparin.
利用体外试验比较了硫酸乙酰肝素（HS）和硫酸皮肤素（DS）与肝素的纤溶和抗凝活性。我们的结果表明，HS比肝素和DS具有更高的促纤溶活性。尽管HS抑制因子IIa的效力比肝素低50倍，但其活性比DS高3倍。HS的作用在于HCH介导的因子IIa抑制与ATIII介导的抑制相结合。DS对ATIII介导的因子IIa抑制没有作用。三种化合物抗凝活性的比较证实，与肝素相比，HS和DS的抗凝作用非常有限。
