Pastolero G, Hanna W, Zbieranowski I, Kahn H J
Department of Pathology, Women's College Hospital, Toronto, Ontario, Canada.
Mod Pathol. 1996 Mar;9(3):215-9.
Adenoid cystic carcinoma is a rare type of invasive breast carcinoma that has a good prognosis. We studied a series of four cases of adenoid cystic carcinoma in which we correlated the clinical and pathological features. The pathological features examined included light microscopy; electron microscopy; immunohistochemistry using antibodies to keratin, vimentin, S100 protein, actin, estrogen and progesterone receptors, and proliferation marker MiB-1, and p53 suppressor protein; image cytometric analysis for measurement of DNA ploidy; and molecular analysis using polymerase chain reaction single strand conformation polymorphism to assess point mutation of the p53 gene. All of the cases had a low nuclear grade, were negative for estrogen and progesterone receptors, and were DNA diploid. Three of the cases showed no evidence of metastases and had small primary tumors with low proliferative activity and absence of p53 protein expression. In contrast, one of the cases showed axillary lymph node metastases and in this case the primary tumor was large with a higher proliferative activity and expression of p53 protein, suggesting that these factors might play a role in the biological behavior of adenoid cystic carcinoma.
腺样囊性癌是一种罕见的浸润性乳腺癌，预后良好。我们研究了一系列4例腺样囊性癌病例，并对其临床和病理特征进行了相关性分析。所检查的病理特征包括光学显微镜检查；电子显微镜检查；免疫组织化学，使用针对角蛋白、波形蛋白、S100蛋白、肌动蛋白、雌激素和孕激素受体以及增殖标志物MiB-1和p53抑癌蛋白的抗体；图像细胞术分析以测量DNA倍体；以及使用聚合酶链反应单链构象多态性进行分子分析以评估p53基因的点突变。所有病例核分级均较低，雌激素和孕激素受体均为阴性，且为DNA二倍体。其中3例无转移证据，原发肿瘤较小，增殖活性低且无p53蛋白表达。相比之下，其中1例出现腋窝淋巴结转移，该病例原发肿瘤较大，增殖活性较高且有p53蛋白表达，提示这些因素可能在腺样囊性癌的生物学行为中起作用。
