Miyai Kosuke, Schwartz Mary R, Divatia Mukul K, Anton Rose C, Park Yong Wook, Ayala Alberto G, Ro Jae Y
Kosuke Miyai, Mary R Schwartz, Mukul K Divatia, Rose C Anton, Alberto G Ayala, Jae Y Ro, Department of Pathology and Genomic Medicine, Houston Methodist Hospital, Weill Medical College of Cornell University, Houston, TX 77030, United States.
World J Clin Cases. 2014 Dec 16;2(12):732-41. doi: 10.12998/wjcc.v2.i12.732.
Adenoid cystic carcinoma (ACC) of the breast is a rare special subtype of breast cancer characterized by the presence of a dual cell population of luminal and basaloid cells arranged in specific growth patterns. Most breast cancers with triple-negative, basal-like breast features (i.e., tumors that are devoid of estrogen receptor, progesterone receptor, and human epidermal growth factor receptor 2 expression, and express basal cell markers) are generally high-grade tumors with an aggressive clinical course. Conversely, while ACCs also display a triple-negative, basal-like phenotype, they are usually low-grade and exhibit an indolent clinical behavior. Many discoveries regarding the molecular and genetic features of the ACC, including a specific chromosomal translocation t(6;9) that results in a MYB-NFIB fusion gene, have been made in recent years. This comprehensive review provides our experience with the ACC of the breast, as well as an overview of clinical, histopathological, and molecular genetic features.
乳腺腺样囊性癌（ACC）是一种罕见的特殊类型乳腺癌，其特征是存在管腔细胞和基底样细胞的双细胞群，并以特定的生长模式排列。大多数具有三阴性、基底样乳腺特征的乳腺癌（即缺乏雌激素受体、孕激素受体和人表皮生长因子受体2表达且表达基底细胞标志物的肿瘤）通常是高级别肿瘤，临床病程具有侵袭性。相反，虽然ACC也表现出三阴性、基底样表型，但它们通常是低级别肿瘤，临床行为惰性。近年来，关于ACC的分子和遗传特征有许多发现，包括导致MYB-NFIB融合基因的特定染色体易位t(6;9)。本综述全面介绍了我们在乳腺ACC方面的经验，以及临床、组织病理学和分子遗传学特征的概述。
