Brook I
Department of Pediatrics, Georgetown University School of Medicine, Washington DC, USA.
Scand J Infect Dis. 1995;27(6):619-22. doi: 10.3109/00365549509047077.
The quantitative aerobic and anaerobic microbiology of bronchial aspirates, obtained using protective brush catheters, from 10 children with ventilator-associated pneumonia, is presented. Aerobic or faculative organisms only were isolated in 1 child, anaerobic bacteria only in 3, and aerobic mixed with anaerobic bacteria in 6. There were 10 aerobic or faculative and 17 anaerobic isolates. The predominant aerobes were Pseudomonas aeruginosa (2 isolates) and Klebsiella sp. (2). The predominant anaerobes were pigmented Prevotella and Porphyromonas species (5), Peptostreptococcus sp. (4), Fusobacterium sp. and B. fragilis group (2). A total of 10 beta-lactamase-producing aerobic and anaerobic bacteria were isolated in 8 patients. All patients except 1 responded to antimicrobial therapy directed against the recovered isolates. These data highlight the polymicrobial aerobic-anaerobic flora isolated from pulmonary specimens of patients with ventilator-associated pneumonia.
本文呈现了使用保护性毛刷导管从10名呼吸机相关性肺炎儿童获取的支气管吸出物的需氧和厌氧定量微生物学情况。仅分离出需氧或兼性生物的有1名儿童，仅分离出厌氧细菌的有3名，需氧菌与厌氧菌混合的有6名。有10株需氧或兼性菌和17株厌氧菌分离株。主要需氧菌为铜绿假单胞菌（2株分离株）和克雷伯菌属（2株）。主要厌氧菌为产色素普雷沃菌属和卟啉单胞菌属（5株）、消化链球菌属（4株）、梭杆菌属和脆弱拟杆菌群（2株）。8名患者共分离出10株产β-内酰胺酶的需氧和厌氧细菌。除1名患者外，所有患者对抗针对分离出的菌株的抗菌治疗均有反应。这些数据突出了从呼吸机相关性肺炎患者肺部标本中分离出的多微生物需氧-厌氧菌群。
