Cortes D, Thorup J M, Nielsen O H, Beck B L
Rigshospitalet, København, børnekirurgisk klinik.
Ugeskr Laeger. 1996 May 13;158(20):2845-8.
In a retrospective study of the case reports of 136 boys who were operated on for an imperforate anus and who survived at least 18 months, cryptorchidism was the most common associated anomaly, involving 26 cases (19%). The higher the level of the anorectal malformations, the higher was the incidence of cryptorchidism. The incidence of renal and ureteric malformations and dysplasias showed a parallel tendency. The incidence of vertebral malformations and dysplasias in the T10-S5 area was low among patients with a covered anus or a perineal fistula. Cryptorchidism was found to be associated with urological and with T10-S5 vertebral malformations and dysplasias. Recognition of this association is probably new. The histopathological findings of testicular biopsy specimens and the location of the undescended testes in patients with an imperforate anus showed the same pattern as seen in undescended testes from patients with cryptorchidism only. These findings, together with the existing literature on the subject, indicate that further studies on the association of cryptorchidism, urological, and T10-S5 vertebral malformations and dysplasias may be important for a better understanding of cryptorchidism in general.
在一项对136例肛门闭锁且存活至少18个月的男孩病例报告的回顾性研究中,隐睾是最常见的相关异常,有26例(19%)。肛门直肠畸形的位置越高,隐睾的发生率越高。肾脏和输尿管畸形及发育异常的发生率呈现平行趋势。在肛门闭锁或会阴瘘患者中,T10 - S5区域的脊柱畸形及发育异常的发生率较低。发现隐睾与泌尿系统以及T10 - S5脊柱畸形及发育异常有关。认识到这种关联可能是新的发现。肛门闭锁患者睾丸活检标本的组织病理学发现以及隐睾的位置与仅患有隐睾症患者的隐睾所见模式相同。这些发现,连同关于该主题的现有文献,表明对隐睾、泌尿系统以及T10 - S5脊柱畸形及发育异常之间关联的进一步研究可能对更好地理解一般隐睾症很重要。