Gotsadze D T, Alkhanishvili K B, Mamaladze V T
Urol Nefrol (Mosk). 1995 Nov-Dec(6):44-7.
Of 322 patients with squamous cell carcinoma of the penis, conservative therapy was conducted in 162 (50.3%) untreated patients free of metastases to regional lymph nodes. 125, 14 and 23 patients received radiation, drug and drug+radiation treatment, respectively. The efficacy of conservative treatment reached 74.6%, complete regression of the tumor was achieved in 61.1% of the cases. 8 patients with partial response (reduction of the tumor to 1 cm in size) were exposed to cryodestruction of the residual tumor. Thus, in 111 of 162 patients the penis was not amputated. Follow-up results show that within the period 4.5-14 years the disease relapsed in 20 of 111 patients, 4 patients throughout follow-up month 3-6 developed metastases to regional lymph nodes in the absence of recurrent tumor. It is concluded that amputation of the penis in early cancer should be made only in uneffective sparing therapy.
在322例阴茎鳞状细胞癌患者中，对162例（50.3%）未接受治疗且无区域淋巴结转移的患者进行了保守治疗。125例、14例和23例患者分别接受了放疗、药物治疗和药物+放疗治疗。保守治疗的有效率达到74.6%，61.1%的病例实现了肿瘤完全消退。8例部分缓解（肿瘤缩小至1厘米大小）的患者接受了残余肿瘤的冷冻消融治疗。因此，162例患者中有111例未进行阴茎截肢。随访结果显示，在4.5至14年期间，111例患者中有20例疾病复发，4例在随访第3至6个月期间在无复发性肿瘤的情况下出现区域淋巴结转移。结论是，早期癌症患者只有在保肢治疗无效时才应进行阴茎截肢。
