Siegelová J, Fiser B, Dusek J
Ustav patologické fyziologie LF MU, Brno.
Vnitr Lek. 1996 Feb;42(2):98-101.
The aim of the present paper was to study 24-h blood pressure profile in twenty patients with essential hypertension (mild to moderate) before and after treatment with ACE inhibitor enalapril in one day dose in the morning (15.6 +/- 6.1 mg). 24-h ambulatory blood pressure monitoring was examined after 14 days of placebo administration and after one month of enalapril therapy. Enalapril treatment decreased systolic blood pressure of 11.3 mmHg during daytime and of 9.4 mmHg at night, diastolic blood pressure of 6.1 mmHg during daytime and 5.8 mmHg at night, all differences were significant in comparison to placebo (p < 0.01). The through-peak ratios were 63.2% for systolic blood pressure and 54.0% for diastolic blood pressure. We can conclude that enalapril treatment in one day morning dose is efficient to decrease blood pressure during 24-h span without altering the diurnal profile.
本研究旨在探讨20例原发性高血压（轻度至中度）患者在早晨服用一日剂量的ACE抑制剂依那普利（15.6 +/- 6.1毫克）治疗前后的24小时血压情况。在服用安慰剂14天后和依那普利治疗1个月后进行24小时动态血压监测。依那普利治疗使白天收缩压降低11.3 mmHg，夜间降低9.4 mmHg；白天舒张压降低6.1 mmHg，夜间降低5.8 mmHg。与安慰剂相比，所有差异均具有统计学意义（p < 0.01）。收缩压的谷峰比为63.2%，舒张压的谷峰比为54.0%。我们可以得出结论，早晨服用一日剂量的依那普利可有效降低24小时血压，且不改变昼夜血压模式。
