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一氧化氮在动脉粥样硬化进展和消退中的作用。

Role of nitric oxide in progression and regression of atherosclerosis.

作者信息

Cooke J P

机构信息

Division of Cardiovascular Medicine, Stanford University School of Medicine, CA 94305-5246, USA.

出版信息

West J Med. 1996 May;164(5):419-24.

PMID:8686299
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1303540/
Abstract

Endothelium-derived nitric oxide is a potent endogenous vasodilator that is derived from the metabolism of L-arginine. This endothelial factor inhibits circulating blood elements from interacting with the vessel wall. Platelet adherence and aggregation as well as monocyte adherence and infiltration are opposed by this paracrine substance. By virtue of these characteristics, endothelium-derived nitric oxide inhibits atherogenesis in animal models and may even induce regression.

摘要

内皮源性一氧化氮是一种强效的内源性血管舒张剂，由L-精氨酸代谢产生。这种内皮因子可抑制循环血液成分与血管壁相互作用。这种旁分泌物质可对抗血小板黏附和聚集以及单核细胞黏附和浸润。凭借这些特性，内皮源性一氧化氮在动物模型中可抑制动脉粥样硬化的发生，甚至可能促使其消退。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6b/1303540/2362427d877c/westjmed00356-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6b/1303540/2362427d877c/westjmed00356-0036-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ee6b/1303540/2362427d877c/westjmed00356-0036-a.jpg

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本文引用的文献

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Regression or progression. Dependency on vascular nitric oxide.消退或进展。对血管一氧化氮的依赖性。
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L-arginine inhibits balloon catheter-induced intimal hyperplasia.L-精氨酸可抑制球囊导管诱导的内膜增生。
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Dietary arginine prevents atherogenesis in the coronary artery of the hypercholesterolemic rabbit.饮食中的精氨酸可预防高胆固醇血症兔子冠状动脉的动脉粥样硬化形成。
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L-arginine improves endothelium-dependent vasorelaxation and reduces intimal hyperplasia after balloon angioplasty.L-精氨酸可改善内皮依赖性血管舒张，并减少球囊血管成形术后的内膜增生。
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Enhanced endothelial adhesiveness in hypercholesterolemia is attenuated by L-arginine.高胆固醇血症中增强的内皮黏附性被L-精氨酸减弱。
Circulation. 1994 May;89(5):2176-82. doi: 10.1161/01.cir.89.5.2176.
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Is NO an endogenous antiatherogenic molecule?一氧化氮是一种内源性抗动脉粥样硬化分子吗？
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Effect of L-arginine on coronary endothelial function in cardiac transplant recipients. Relation to vessel wall morphology.L-精氨酸对心脏移植受者冠状动脉内皮功能的影响。与血管壁形态的关系。
Circulation. 1994 Apr;89(4):1615-23. doi: 10.1161/01.cir.89.4.1615.
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Nitric oxide inhibits macrophage-colony stimulating factor gene transcription in vascular endothelial cells.一氧化氮抑制血管内皮细胞中巨噬细胞集落刺激因子基因的转录。
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