Aicher B, Kraupp O
Abteilung Medizinische Wissenschaft, Dr. Karl Thomae GmbH, Biberach, Bundesrepublik Deutschland.
Wien Klin Wochenschr. 1996;108(8):219-33.
Thomapyrin has been on the German market as analgesic for the past 50 years. It is the prescription-free preparation with the highest sales there. This is an occasion to survey current state of scientific knowledge concerning combination analgesics with acetyl salicylic acid, paracetamol and caffeine. For the assessment and registration of fixed preparations authorities of different European countries and also USA have defined special criteria. Analgesic preparations must agree with these defined criteria. The importance of these combination analgesics in pain therapy is described with the respect to the latest scientific results. Combination analgesics represent an important area of self-medication by the patient. The properties of the active substances alone and in combination are set forth, with respect to pharmacokinetics and efficacy. The experimental and especially clinical results clearly show a broader spectrum of action in consequence of the different modes of action of the individual active substances. Analgesic action is 1.4 fold higher owing to added caffeine. The fixed combination of active substances does not change the profile of side effects. The conclusion is that combination analgesics such as Thomapyrine show a positive benefit/risk ratio. Furthermore such combination analgesics are appropriate for self-medications and suited to combat pain of different kinds.
过去50年来，索密痛一直在德国市场作为镇痛药销售。它是德国销量最高的非处方药。借此机会，对有关含乙酰水杨酸、对乙酰氨基酚和咖啡因的复方镇痛药的科学知识现状进行调查。不同欧洲国家以及美国的相关部门针对固定复方制剂的评估和注册制定了特殊标准。镇痛制剂必须符合这些既定标准。结合最新科学成果，阐述了这些复方镇痛药在疼痛治疗中的重要性。复方镇痛药是患者自我药疗的一个重要领域。文中阐述了活性物质单独使用及联合使用时在药代动力学和疗效方面的特性。实验尤其是临床结果清楚地表明，由于各活性物质的作用方式不同，联合使用具有更广泛的作用谱。由于添加了咖啡因，镇痛作用提高了1.4倍。活性物质的固定组合并未改变副作用的情况。结论是，像索密痛这样的复方镇痛药显示出良好的效益/风险比。此外，这类复方镇痛药适合自我药疗，适合对抗各种疼痛。
