[1型和2型糖尿病患者的血清尿酸水平]

[Serum uric acid level in type 1 and type 2 diabetic patients].

作者信息

Zazgornik J, Biesenbach G, Janko O, Grafinger P, Kaiser W, Stuby U, Hubmann R

机构信息

II. Medizinischen Abteilung, Allgemeinen Krankenhauses der Stadt Linz.

出版信息

Wien Med Wochenschr. 1996;146(5):102-4.

PMID:8686325

Abstract

In 50 type-1 and 50 type-2 diabetic patients serum uric acid levels were measured. Type-1 diabetics showed significantly lower serum uric acid levels in comparison to type-2 diabetics (p < 0.02). This significant difference has been observed in both women (p < 0.001) and men (p < 0.01). Serum uric acid level was lower in type-1 diabetics than in healthy controls but only in diabetic men the difference was statistically significant (p < 0.001). Male type-2 diabetic patients showed serum uric acid levels similar to the controls, but levels were higher in women with type-2 diabetes (p < 0.001). The results of this study show that in type-1 diabetic patients the serum uric acid levels are lower in normal (creatinine clearance > or = 80 ml/min) as well as in slightly decreased (creatinine clearance < 80 ml/min) glomerular filtration rate. But in type-2 diabetic patients the serum uric acid levels were significantly higher when glomerular filtration rate was below 80 ml/min in contrast to normal renal function (p < 0.05).

摘要

对50例1型糖尿病患者和50例2型糖尿病患者的血清尿酸水平进行了测量。与2型糖尿病患者相比，1型糖尿病患者的血清尿酸水平显著降低（p<0.02）。在女性（p<0.001）和男性（p<0.01）中均观察到了这种显著差异。1型糖尿病患者的血清尿酸水平低于健康对照组，但仅在糖尿病男性中差异具有统计学意义（p<0.001）。男性2型糖尿病患者的血清尿酸水平与对照组相似，但2型糖尿病女性患者的血清尿酸水平更高（p<0.001）。本研究结果表明，在1型糖尿病患者中，正常（肌酐清除率≥80 ml/min）以及轻度降低（肌酐清除率<80 ml/min）的肾小球滤过率情况下，血清尿酸水平均较低。但在2型糖尿病患者中，与正常肾功能相比，当肾小球滤过率低于80 ml/min时，血清尿酸水平显著升高（p<0.05）。