Croucher P I, Gilks W R, Compston J E
Department of Medicine, University of Cambridge Clinical School, UK.
J Bone Miner Res. 1995 Oct;10(10):1537-43. doi: 10.1002/jbmr.5650101015.
Bone resorption and formation are coupled both in time and space and may occur simultaneously in the same remodeling unit. A number of studies have shown that the formative phase of the remodeling sequence may undergo temporary interruptions prior to completion and it is possible that bone resorption may be subject to similar interruptions. We have investigated this hypothesis by studying the distribution of eroded depth in resorption cavities in human cancellous bone. Eroded depth was assessed in iliac crest cancellous bone from 41 normal healthy subjects using a cubic spline curve fitting technique. The distribution of mean eroded depths was skewed to the right. Comparison of the observed distribution with an expected distribution, which was calculated from previously published data and assumes resorption begins rapidly and slows as it approaches completion, showed a significantly greater proportion of shallower cavities than expected (p<0001). Similarly, comparison of observed and uniform distributions, which assumes a constant rate of resorption throughout the erosion period, also showed a significantly greater proportion of smaller cavities (p<0.01). In subjects aged less than 39 years, there were fewer small cavities than in those aged 40-59 years. In addition, there was some evidence that females of 40-59 years had a proportionately greater number of smaller cavities than males; however, there were no differences in other age groups. Our results demonstrate a significantly greater proportion of smaller resorption cavities than would be expected from current models of bone remodeling and are consistent with the hypothesis that resorption undergoes temporary interruptions and/or permanent arrest during the process of bone remodeling.
骨吸收和骨形成在时间和空间上都是相互关联的，并且可能在同一个重塑单元中同时发生。大量研究表明，重塑序列的形成阶段在完成之前可能会经历暂时中断，并且骨吸收也可能受到类似的中断。我们通过研究人松质骨吸收腔中侵蚀深度的分布来探讨这一假设。使用三次样条曲线拟合技术评估了41名正常健康受试者髂嵴松质骨的侵蚀深度。平均侵蚀深度的分布向右偏斜。将观察到的分布与预期分布进行比较，预期分布是根据先前发表的数据计算得出的，假设吸收开始时迅速，接近完成时减缓，结果显示较浅的腔隙比例明显高于预期（p<0.001）。同样，将观察到的分布与均匀分布进行比较，均匀分布假设在整个侵蚀期吸收速率恒定，结果也显示较小腔隙的比例明显更高（p<0.01）。在年龄小于39岁的受试者中，小腔隙比40 - 59岁的受试者少。此外，有证据表明40 - 59岁的女性较小腔隙的比例相对高于男性；然而，在其他年龄组中没有差异。我们的结果表明，与当前的骨重塑模型预期相比，较小吸收腔隙的比例明显更高，这与骨重塑过程中吸收会经历暂时中断和/或永久停滞的假设一致。
