Togashi M, Tabata T, Hirakawa K, Ohashi N, Sindoh J, Hirano T, Demura T
Department of Urology, Sapporo City General Hospital, Japan.
Hinyokika Kiyo. 1996 Jan;42(1):43-5.
Three patients with lung metastases of renal cell carcinoma (RCC) were treated with a combination of interferon-alpha, leucovorin and 5-fluorouracil. All patients were male between 60 and 66 years and had been treated by nephrectomy prior to the combination therapy. Interferon-alpha was administered at the dose of 9 x 10(6) IU intramuscularly 3 times/week, leucovorin at 30 mg/m2 per day intravenously (day 1 to 5) and 5-fluorouracil at 500 mg/m2 daily by continuous infusion intravenously (day 1 to 5) followed by weekly bolus therapy. One patient achieved complete response for 17 months and the other two achieved stable disease for 6 and 16 months. Side effects related to this therapy were diarrhea, stomatitis, alopecia, leucocytopenia and thrombocytopenia. Grade 3 stomatitis occurred after the continuous administration of 5-fluorouracil in one patient; he recovered by discontinuation of 5-fluorouracil. Combination therapy with interferon-alpha, leucovolin and 5-fluorouracil might be effective for the treatment of lung metastases of RCC.
三名肾细胞癌（RCC）肺转移患者接受了α-干扰素、亚叶酸钙和5-氟尿嘧啶联合治疗。所有患者均为男性，年龄在60至66岁之间，在联合治疗前均已接受肾切除术。α-干扰素以9×10⁶IU的剂量每周肌肉注射3次，亚叶酸钙以30mg/m²的剂量每天静脉注射（第1至5天），5-氟尿嘧啶以500mg/m²的剂量每天静脉持续输注（第1至5天），随后进行每周一次的推注治疗。一名患者达到完全缓解17个月，另外两名患者病情稳定6个月和16个月。该治疗的副作用包括腹泻、口腔炎、脱发、白细胞减少和血小板减少。一名患者在持续输注5-氟尿嘧啶后出现3级口腔炎；通过停用5-氟尿嘧啶后恢复。α-干扰素、亚叶酸钙和5-氟尿嘧啶联合治疗可能对RCC肺转移的治疗有效。
