Verneuil L, Dompmartin A, Duhamel C, Cren P, Six M, Le Maitre M, Galateau F, Moreau A, Leroy D
Service de Dermatologie, CHU, Caen.
Ann Dermatol Venereol. 1995;122(10):688-91.
Cutaneous cryptococcosis is a systemic fungal disease; it is commonly observed in immunocompromised patients.
We report the case of a cryptococcal whitlow in an HIV positive patient. The mycologic culture of the cutaneous lesion was positive for Cryptococcus neoformans serotype D. The detection of the blood antigen was positive but there was no pulmonary nor central nervous system involvement. The lesions cured with fluconazole (400 mg/day during 2 months and 200 mg/day after).
This unusual clinical presentation of cutaneous cryptococcosis has never been reported in an HIV positive patient. As the dermatologic manifestations of cryptococcosis are polymorphous mycologic examination of skin lesions is very important.
皮肤隐球菌病是一种全身性真菌病；常见于免疫功能低下的患者。
我们报告一例HIV阳性患者发生隐球菌性甲沟炎的病例。皮肤病变的真菌培养显示新型隐球菌D血清型阳性。血液抗原检测呈阳性，但无肺部及中枢神经系统受累。病变经氟康唑治疗（最初2个月每天400毫克，之后每天200毫克）后治愈。
这种皮肤隐球菌病的不寻常临床表现从未在HIV阳性患者中报道过。由于隐球菌病的皮肤表现具有多形性，对皮肤病变进行真菌学检查非常重要。
