Causse J, Shambaugh G E, Chevance L G, Bretlau P
Adv Otorhinolaryngol. 1977;22:43-56. doi: 10.1159/000399488.
First, the authors discuss the most valuable way to correlate specific morphological changes encountered in cochlear otospongiosis with sensorineural hearing loss. They think that biochemical factors may be responsible for this association of cochlear otospongiosis and histopathologic changes, and they explain their enzymatic concept resulting from experimental findings and cyto-clinical relationship. Second, the authors analyze clinical, audiometric and X-Rays investigations enabling the diagnosis of cochlear otospongiosis, in its pure pereceptive form as well as in the perceptive component added to the conductive loss in far-advanced mixed audiometric types in surgical otospongiosis. They present two typical cases of cochlear otospongiosis: one combines clinical history, audiometric test and post mortem investigations;-the other shows the passage from a pure cochlear otospongiosis to a secondary stapedial fixation, ten years later, thus confirming by audiometric data and by stapedectomy the otospongiotic etiology of this previous pure sensorineural loss. Finally, they insist upon the great interest of establishing an early diagnosis in cochlear otospongiosis on account of its therapeutic implication, particularly from the enzymatic point of view.
首先，作者探讨了将耳蜗耳硬化症中出现的特定形态学变化与感音神经性听力损失相关联的最有价值的方法。他们认为生化因素可能是耳蜗耳硬化症与组织病理学变化之间这种关联的原因，并解释了基于实验结果和细胞临床关系得出的酶学概念。其次，作者分析了临床、听力测定和X射线检查，这些检查能够诊断耳蜗耳硬化症，包括其单纯的感知形式以及在外科耳硬化症晚期混合听力测定类型中传导性损失附加的感知成分。他们展示了两个耳蜗耳硬化症的典型病例：一个结合了临床病史、听力测试和尸检调查；另一个显示了十年后从单纯的耳蜗耳硬化症发展为继发性镫骨固定，从而通过听力数据和镫骨切除术证实了先前单纯感音神经性听力损失的耳硬化病因。最后，他们强调鉴于耳蜗耳硬化症的治疗意义，尤其是从酶学角度来看，早期诊断具有极大的重要性。
