Owen P, Duncan I D
Department of Obstetrics and Gynaecology, Ninewells Hospital and Medical School, Dundee, UK.
Br J Obstet Gynaecol. 1996 Jul;103(7):710-3. doi: 10.1111/j.1471-0528.1996.tb09843.x.
To evaluate the clinical benefit of routine follow up of women after treatment for endometrial adenocarcinoma.
Retrospective case analysis.
All cases diagnosed and treated for endometrial adenocarcinoma in Tayside, Scotland during 1982 to 1984 inclusive.
Case-note and cancer registration document review.
Of 102 patients, 97 had complete follow up for 10 years or until death. Recurrent disease was diagnosed in 17 women, only six of whom were asymptomatic at the time of diagnosis. There was no difference in survival between cases with symptomatic and asymptomatic recurrences. No recurrences were diagnosed more than six years after initial diagnosis.
The diagnosis of asymptomatic recurrent endometrial carcinoma was not associated with improved long term survival. This small study showed no evidence of improved survival from the current practice of routine clinical review following treatment for endometrial adenocarcinoma. The effect of follow up on patient anxiety remains to be assessed.
评估子宫内膜腺癌治疗后对女性进行常规随访的临床益处。
回顾性病例分析。
1982年至1984年(含)期间在苏格兰泰赛德被诊断并接受子宫内膜腺癌治疗的所有病例。
查阅病例记录和癌症登记文件。
102例患者中,97例进行了为期10年的完整随访或直至死亡。17名女性被诊断为疾病复发,其中只有6例在诊断时无症状。有症状复发和无症状复发的病例在生存率上没有差异。初次诊断后六年以上未诊断出复发病例。
无症状复发性子宫内膜癌的诊断与长期生存率的提高无关。这项小型研究没有证据表明,目前对子宫内膜腺癌治疗后进行常规临床复查的做法能提高生存率。随访对患者焦虑的影响仍有待评估。