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[老年之家精神药物使用的流行病学]

[Epidemiology of psychotropic drug utilization in homes for the aged].

作者信息

Weyerer S, el-Barrawy R, König S, Zimber A

机构信息

Zentralinstitut für Seelische Gesundheit, Mannheim.

出版信息

Gesundheitswesen. 1996 Apr;58(4):201-6.

PMID:8688570
Abstract

Cross-sectional studies conducted in 1988 and 1992 using identical assessment methods also determined the prevalence of psychotropic drug consumption by the residents of homes for the elderly in the city of Mannheim. Another purpose of the studies was to find out the extent of a possible interrelation between treatment with psychotropics on the one hand and sociodemographic sociodemographic characteristics and behaviour problems of the residents on the other. In addition, in all consecutive new admissions to the homes not only the prevalence of consumption of psychotropics was investigated, but also the question to what extent the use of psychotropic drugs increases the mortality rate. In a total of 12 Mannheim old-age homes each in 1988 (n = 542) and 1992 (n = 497) all the residents older than 65 years of age were investigated. Between 1986 and 1988 all consecutive admissions (n = 239) to Mannheim old-age homes were interviewed and the mortality risk determined in a subsequent investigation in 1992. Taking a period of four weeks as reference period, 42.1% of the residents were treated during that period with psychotropics in 1988, of which 13.3% received neuroleptics, 11.7% hypnotics, 8.9% antidepressants and 13.0% tranquilizers. There were considerable variations between the individual homes in respect of the intake of psychotropics (minimum 18.2%, maximum 58.3%). In 1992 the prevalence of the use of psychotropics rose to 47.6%, the increase being mainly due to neuroleptics (23.8%) and, to a lesser extent, to antidepressants (12.9%). Compared with 1988 there was a slight decrease in the consumption of tranquilizers (10.9%) and hypnotics (10.7%). In 1988 there was no statistically significant connection between intake of psychotropics and gender, age, frequency of visits by relatives/friends, duration of residence and behaviour problems (aggression, suspiciousness, wandering, depression, dementia) of the residents. This result was also confirmed for 1992, albeit with two exceptions: a significantly higher consumption of psychotropic drugs by home residents characterised by the "behaviour problems wandering" and "depression". Examination of the consecutively newly admitted inmates revealed that psychotropic drug consumption was already relatively high (38.0%) at the time of admission. The mortality risk, determined after having checked on possibly confounding variables, was not significantly enhanced in residents who had already been treated with psychotropics at the time of admission (odds ratio: 0.52; Cl: 0.25-1.08). Compared with elderly persons in private households the consumption of psychotropics is markedly higher in old-age homes. However, the intake is not due to institutionalisation, but had already been high at the time of admission. Prospective studies of the course with relatively short follow-up intervals would be necessary for a differentiated examination of the determinants and effects of high psychotropics consumption and to establish a sound foundation for an appropriate prescription of psychotropics for home residents.

摘要

1988年和1992年采用相同评估方法进行的横断面研究还确定了曼海姆市老年之家居民使用精神药物的患病率。这些研究的另一个目的是找出一方面使用精神药物治疗与另一方面居民的社会人口学特征和行为问题之间可能存在的相互关系程度。此外,在所有连续新入住这些机构的老人中,不仅调查了使用精神药物的患病率,还调查了使用精神药物在多大程度上会增加死亡率。1988年(n = 542)和1992年(n = 497),在曼海姆市总共12家养老院中,对所有65岁以上的居民进行了调查。1986年至1988年期间,对曼海姆养老院所有连续入院的老人(n = 239)进行了访谈,并在1992年的后续调查中确定了死亡风险。以四周为参考期,1988年期间42.1%的居民接受了精神药物治疗,其中13.3%使用了抗精神病药物,11.7%使用了催眠药,8.9%使用了抗抑郁药,13.0%使用了镇静剂。各养老院在精神药物的使用方面存在很大差异(最低18.2%,最高58.3%)。1992年,精神药物的使用率上升至47.6%,增长主要归因于抗精神病药物(23.8%),其次是抗抑郁药(12.9%)。与1988年相比,镇静剂(10.9%)和催眠药(10.7%)的使用量略有下降。1988年,居民使用精神药物与性别、年龄、亲属/朋友探访频率、居住时间以及行为问题(攻击行为、多疑、徘徊、抑郁、痴呆)之间没有统计学上的显著关联。1992年这一结果也得到了证实,不过有两个例外:以“徘徊行为问题”和“抑郁”为特征的养老院居民使用精神药物的量明显更高。对连续新入院的老人进行检查发现,入院时精神药物的使用率就已经相对较高(38.0%)。在检查了可能的混杂变量后确定,入院时已经接受精神药物治疗的居民的死亡风险没有显著增加(优势比:0.52;可信区间:0.25 - 1.08)。与私人家庭中的老年人相比,养老院中精神药物的使用量明显更高。然而,这种使用量并非因入住养老院所致,而是在入院时就已经很高。为了对高精神药物使用量的决定因素和影响进行细致研究,并为养老院居民合理开具精神药物建立坚实基础,有必要进行随访间隔相对较短的前瞻性病程研究。

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