Morandi S, Manna A, Sabattini E, Porcellini A
Section of Hematology and BMT Center Cremona General Hospital, Cremona, Italy.
J Pediatr Hematol Oncol. 1996 Aug;18(3):305-7. doi: 10.1097/00043426-199608000-00015.
We describe a case of a very unusual presentation of rhabdomyosarcoma.
An 18-year-old woman presented with symptoms and signs compatible with acute leukemia. The bone marrow picture showed diffuse involvement sustained by undifferentiated blasts that turned out to be of striated muscle origin by immunochemistry. While it is well known that rhabdomyosarcoma may metastasize to the bone marrow, extensive marrow involvement with leukemic spread as a unique clinical manifestation is extremely rare.
Our observation further confirms the need to consider rhabdomyosarcoma among the possible differential diagnoses in patients who present with a leukemic picture and atypical blasts lacking all hematopoietic markers.
我们描述一例横纹肌肉瘤的非常不寻常的表现。
一名18岁女性出现与急性白血病相符的症状和体征。骨髓检查显示弥漫性受累，由未分化的原始细胞构成，免疫化学检查表明这些原始细胞来源于横纹肌。虽然众所周知横纹肌肉瘤可转移至骨髓，但以白血病播散为独特临床表现的广泛骨髓受累极为罕见。
我们的观察进一步证实，对于表现为白血病图像且缺乏所有造血标志物的非典型原始细胞的患者，在可能的鉴别诊断中需要考虑横纹肌肉瘤。
