Langerhans cell histiocytosis and hypercalcemia: clinical response to indomethacin.

PURPOSE

Hypercalcemia is a known complication of childhood malignancies but has never been reported to be associated with Langerhans cell histiocytosis (LCH) in a pediatric patient.

PATIENTS AND METHODS

We describe an infant with multisystem LCH who developed hypercalcemia on two occasions. After being placed on indomethacin, the hypercalcemia did not recur despite disease progression.

CONCLUSION

Hypercalcemia may complicate LCH. If it is demonstrated, indomethacin should be considered as a treatment.