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感染间日疟原虫后西非矮山羊(Capra aegagus hircus)肝脏和脂肪储存的变化。

Changes in liver and fat depots of west African dwarf goats (Capra aegagus hircus) after an infection with T. vivax.

作者信息

Hamminga B J, Wensing T, Zwart D

机构信息

Department of Tropical Animal Husbandry, Wageningen Agriculture University, The Netherlands.

出版信息

Comp Biochem Physiol A Physiol. 1996 Apr;113(4):401-6. doi: 10.1016/0300-9629(95)02082-9.

DOI:10.1016/0300-9629(95)02082-9
PMID:8689524
Abstract

Nine West African dwarf goats (Capra aegagus hircus) were each infected experimentally with 3 x 10(7) Trypanosoma vivax parasites. The changes in the plasma concentration of nonesterified fatty acids (NEFA) were monitored during the infection and the level of hepatic triacylglycerols and glycogen was measured postmortem. During the infection they had higher plasma NEFA concentrations than nine uninfected control goats and at postmortem their total liver triacylglycerol and glycogen contents were found to be increased. These observations suggest that the mobilization of the goats' defense mechanisms against the T. vivax infection induced a more intensive fat mobilization resulting in changes in fat metabolism of the liver.

摘要

九只西非矮山羊(Capra aegagus hircus)每只都通过实验感染了3×10⁷ 间日锥虫寄生虫。在感染期间监测了非酯化脂肪酸(NEFA)的血浆浓度变化,并在死后测量了肝脏三酰甘油和糖原的水平。在感染期间,它们的血浆NEFA浓度高于九只未感染的对照山羊,并且在死后发现它们肝脏中的总三酰甘油和糖原含量增加。这些观察结果表明,山羊针对间日锥虫感染的防御机制的动员诱导了更强烈的脂肪动员,从而导致肝脏脂肪代谢发生变化。

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