Schafer D A, Cooper J A
Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
Annu Rev Cell Dev Biol. 1995;11:497-518. doi: 10.1146/annurev.cb.11.110195.002433.
Actin filament polymerization involves exchange of subunits of filament ends, which can be controlled in vitro and in vivo by other proteins that bind actin filaments and inhibit subunit addition or loss at the ends. Proteins that bind to the barbed end, including capping protein, the gelsolin super-family, tensin, and profilin are discussed, as are proteins that bind to the pointed end, including tropomodulin and spectrin/band 4.1. Some proteins that bind along the sides of filaments and influence assembly at ends are also discussed. Functional roles in vivo are emphasized.
肌动蛋白丝聚合涉及丝末端亚基的交换，在体外和体内，这一过程可由其他结合肌动蛋白丝并抑制末端亚基添加或丢失的蛋白质来控制。本文讨论了结合到肌动蛋白丝的刺端的蛋白质，包括封端蛋白、凝溶胶蛋白超家族、张力蛋白和前纤维蛋白，以及结合到肌动蛋白丝的钝端的蛋白质，包括原肌球蛋白和血影蛋白/带4.1。本文还讨论了一些沿丝侧面结合并影响末端组装的蛋白质。文中强调了它们在体内的功能作用。
