Sakamoto H, Nozaki S, Misumi K, Kurose M, Sohara H, Amitani S, Miyahara K
Department of Veterinary Medicine, Faculty of Agriculture, Kagoshima University, Japan.
Exp Anim. 1996 Jan;45(1):89-93. doi: 10.1538/expanim.45.89.
We examined histologically whether the severity of arterial stretch injury is related to the degree of subsequent intimal hyperplasia. In six male New Zealand White rabbits, the common carotid artery was hyperextended with a 3F Fogarty balloon catheter. Two weeks later, no proliferative change was evident in the intima in the most hyperextended portion. Paradoxically, however, intimal hyperplasia due to smooth muscle cell proliferation was observed in the moderately extended portions. The intimal hyperplasia appeared to be exacerbated where the arterial stretching was more severe. It is concluded that the severity of arterial stretch injury is closely related to the intimal proliferation of smooth muscle cells.
我们通过组织学检查来探究动脉拉伸损伤的严重程度是否与随后内膜增生的程度相关。在六只雄性新西兰白兔中，使用3F Fogarty球囊导管对颈总动脉进行过度伸展。两周后，在伸展最严重的部分内膜未见明显的增殖变化。然而，矛盾的是，在中度伸展的部分观察到了由于平滑肌细胞增殖导致的内膜增生。在动脉拉伸更严重的部位，内膜增生似乎更明显。得出的结论是，动脉拉伸损伤的严重程度与平滑肌细胞的内膜增殖密切相关。
