Endoh T, Suzuki T
Department of Physiology, Tokyo Dental College, Chiba, Japan.
Bull Tokyo Dent Coll. 1995 May;36(2):87-90.
The effects of agonists for delta-opioid receptors on synaptic transmission in hamster submandibular ganglion were studied in vitro, using an intracellular recording technique. [Met5]enkephalinamide (17 microM), [D-Ser2¿Leu-enkephalin-Thr (14 microM) and [D-Pen2, D-Pen5]enkephalin (10 microM), delta selective agonists caused reversible depression of the fast EPSP amplitude in 10 of 30 cells tested. The inhibitory actions of [D-Pen2, D-Pen5]enkephalin were antagonized by ICI 174,864, a delta selective antagonist. Naloxon a non-selective antagonist and ICI 174,864 both also potentiated the fast EPSP amplitude in 5 of 11 cells tested.
采用细胞内记录技术，在体外研究了δ阿片受体激动剂对仓鼠下颌下神经节突触传递的影响。[Met5]脑啡肽酰胺（17微摩尔）、[D-Ser2，Leu-脑啡肽-Thr（14微摩尔）和[D-Pen2，D-Pen5]脑啡肽（10微摩尔），δ选择性激动剂在30个受试细胞中的10个细胞中引起快速兴奋性突触后电位（EPSP）幅度的可逆性降低。[D-Pen2，D-Pen5]脑啡肽的抑制作用被δ选择性拮抗剂ICI 174,864拮抗。非选择性拮抗剂纳洛酮和ICI 174,864在11个受试细胞中的5个细胞中也增强了快速EPSP幅度。
