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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Marunaka Y, Doi Y, Nakahari T

MRC Group in Lung Development and Division of Respiratory Research, University of Toronto Faculty of Medicine, Ontario.

Gen Pharmacol. 1995 Nov;26(7):1513-7. doi: 10.1016/0306-3623(95)00032-1.

We studied the effects of bumetanide (a Na+/K+/2Cl- cotransport inhibitor) and HCO3(-) on beta-adrenergic-agonist-stimulated short-circuit current (beta-Isc) in rat fetal distal lung epithelium (FDLE). 2. Bumetanide significantly increased beta-Isc in the absence of amiloride but decreased it in its presence. The amiloride- and bumetanide-insensitive beta-Isc was diminished by a removal of HCO3(-) in the bathing solution. 3. Our results suggest that bumetanide stimulates the amiloride-sensitive beta-Isc in FDLE and that the amiloride-insensitive beta-Isc is composed of two different pathways: bumetanide-sensitive and HCO3(-)-dependent Cl- secretion in FDLE.

我们研究了布美他尼（一种Na+/K+/2Cl-共转运抑制剂）和HCO3(-)对大鼠胎儿远端肺上皮细胞（FDLE）中β-肾上腺素能激动剂刺激的短路电流（β-Isc）的影响。2. 在不存在阿米洛利的情况下，布美他尼显著增加β-Isc，但在其存在时则降低β-Isc。通过去除浴液中的HCO3(-)，可使对阿米洛利和布美他尼不敏感的β-Isc减少。3. 我们的结果表明，布美他尼刺激FDLE中对阿米洛利敏感的β-Isc，且对阿米洛利不敏感的β-Isc由两种不同途径组成：FDLE中对布美他尼敏感且依赖HCO3(-)的Cl-分泌。

Marunaka Y, Doi Y, Nakahari T

MRC Group in Lung Development and Division of Respiratory Research, University of Toronto Faculty of Medicine, Ontario.

Gen Pharmacol. 1995 Nov;26(7):1513-7. doi: 10.1016/0306-3623(95)00032-1.

We studied the effects of bumetanide (a Na+/K+/2Cl- cotransport inhibitor) and HCO3(-) on beta-adrenergic-agonist-stimulated short-circuit current (beta-Isc) in rat fetal distal lung epithelium (FDLE). 2. Bumetanide significantly increased beta-Isc in the absence of amiloride but decreased it in its presence. The amiloride- and bumetanide-insensitive beta-Isc was diminished by a removal of HCO3(-) in the bathing solution. 3. Our results suggest that bumetanide stimulates the amiloride-sensitive beta-Isc in FDLE and that the amiloride-insensitive beta-Isc is composed of two different pathways: bumetanide-sensitive and HCO3(-)-dependent Cl- secretion in FDLE.

我们研究了布美他尼（一种Na+/K+/2Cl-共转运抑制剂）和HCO3(-)对大鼠胎儿远端肺上皮细胞（FDLE）中β-肾上腺素能激动剂刺激的短路电流（β-Isc）的影响。2. 在不存在阿米洛利的情况下，布美他尼显著增加β-Isc，但在其存在时则降低β-Isc。通过去除浴液中的HCO3(-)，可使对阿米洛利和布美他尼不敏感的β-Isc减少。3. 我们的结果表明，布美他尼刺激FDLE中对阿米洛利敏感的β-Isc，且对阿米洛利不敏感的β-Isc由两种不同途径组成：FDLE中对布美他尼敏感且依赖HCO3(-)的Cl-分泌。