地西泮降低了对蟾蜍尾蟾神经-皮肤标本电刺激的反应。

Diazepam decreases the response to the electrical stimulation of the nerve-skin preparation of the toad Caudiverbera caudiverbera.

Norris B, Nunez G, Contreras G, Contreras E

Department of Physiology, University of Concepción, Chile.

Gen Pharmacol. 1995 Nov;26(7):1607-11. doi: 10.1016/0306-3623(95)00058-5.

Abstract

The effect of diazepam was examined in the nerve skin preparation of the toad Caudiverbera caudiverbera. 2. Nerve stimulation was followed immediately by a transient increase in short-circuit current (SCC) and in the potential difference (PD), which consisted of a rapid and then a slow component. 3. Diazepam concentrations from 5.0 x 10(-5)M to 5.1 x 10(-4)M caused a dose-dependent block of both components to a 30% of their control values and also reduced the stimulatory responses to noradrenaline in this preparation. 4. Diazepam antagonized the potassium blocking effect of barium. 5. These results, based on electrophysiological and pharmacological evidence, are consistent with a calcium and sodium blocking effect of diazepam on the nerve skin junction of C. caudiverbera.

摘要

在尾蟾（Caudiverbera caudiverbera）的神经皮肤标本中研究了地西泮的作用。2. 神经刺激后紧接着短路电流（SCC）和电位差（PD）出现短暂增加，其由一个快速成分和随后的一个缓慢成分组成。3. 浓度为5.0×10⁻⁵M至5.1×10⁻⁴M的地西泮导致两个成分均出现剂量依赖性阻滞，降至其对照值的30%，并且还降低了该标本中对去甲肾上腺素的刺激反应。4. 地西泮拮抗钡的钾阻断作用。5. 基于电生理和药理学证据，这些结果与地西泮对尾蟾神经皮肤连接处的钙和钠阻断作用一致。