Ukai Y, Ogasawara T, Yoshikuni Y, Kimura K
Research Laboratories, Nippon Shinyaku Co., Kyoto, Japan.
Nihon Yakurigaku Zasshi. 1996 Jun;107(6):273-84. doi: 10.1254/fpj.107.273.
Central effects of montirelin hydrate (NS-3) were electroencephalographically investigated in cats with experimentally induced disturbance of consciousness. All experiments were conducted under the gallamine-immobilized and artificially ventilated acute experimental condition. NS-3 and TRH produced EEG activation in cats with lesions in the midbrain reticular formation in a dose-dependent manner. Similar effects were observed in cats with bilateral lesions of the posterior hypothalamic area. These effects of NS-3 were 30 to 100 times more potent than those of TRH. NS-3 at doses higher than 0.003 mg/kg restored the suppressed EEG dose-dependently in cats with cerebral ischemia produced by clamping the bilateral common carotid arteries and basilar artery. TRH showed no effect at a dose of 10 mg/kg. These results indicate that NS-3 might be an effective drug for treating the disturbance of consciousness.
在实验性诱导意识障碍的猫中，通过脑电图研究了水合莫替瑞林（NS - 3）的中枢效应。所有实验均在加拉明固定并人工通气的急性实验条件下进行。NS - 3和促甲状腺激素释放激素（TRH）在中脑网状结构有损伤的猫中以剂量依赖性方式产生脑电图激活。在下丘脑后区双侧损伤的猫中也观察到类似效应。NS - 3的这些效应比TRH强30至100倍。在通过夹闭双侧颈总动脉和基底动脉产生脑缺血的猫中，高于0.003 mg/kg剂量的NS - 3可剂量依赖性地恢复被抑制的脑电图。TRH在10 mg/kg剂量时无作用。这些结果表明NS - 3可能是治疗意识障碍的有效药物。
