Minard P, Murrell K D, Stirewalt M A
Am J Trop Med Hyg. 1977 May;26(3):491-9. doi: 10.4269/ajtmh.1977.26.491.
Schistosoma mansoni cercariae secrete preacetabular gland material in association with skin penetration. The material is heterogeneous and contains proteolytic enzyme(s) which comprise a small proportion of the total protein. We have immunized mice with cercarial secretion material in several protocols designed to induce a variety of antibody responses. The cercarial secretion material is sufficiently immunogenic to induce precipitating and reaginic antibody production. The antibodies obtained were not of the necessary quantity and/or quality to afford protection from a challenge infection.
曼氏血吸虫尾蚴在穿透皮肤时会分泌前吸盘腺物质。该物质具有异质性，含有蛋白水解酶，其在总蛋白中占比小。我们采用了多种方案用尾蚴分泌物质免疫小鼠，以诱导多种抗体反应。尾蚴分泌物质具有足够的免疫原性，可诱导沉淀抗体和反应素抗体产生。所获得的抗体在数量和/或质量上不足以提供针对攻击感染的保护作用。
