Schreij G, Ritsema G H, Vreugdenhil G, de Leeuw P W
Department of Internal Medicine, University Hospital, Maastricht, The Netherlands.
J Nucl Med. 1996 Apr;37(4):594-7.
This study was designed to determine the degree of renal artery stenosis (RAS) which produces changes in renographic parameters.
The angiographic severity of luminal narrowing in RAS was compared to 131I-hippuran renographic characteristics in 72 patients who have been selected for renal angiography because of suspected renovascular hypertension.
Significant differences in Tmax, T1/2 and counts under the curve to Tmax were apparent at 30% of arterial luminal narrowing when stenotic and nonstenotic kidneys were compared. In patients with unilateral RAS, the difference in counts under the Tmax curve between pairs of kidneys was also significantly different at 30% of stenosis. Patients with bilateral stenosis, on the other hand, could not be differentiated well from patients with essential hypertension because the Tmax value on either side or the difference of Tmax between the two kidneys and the values of the other parameters were similar, except for the difference in counts to Tmax. Based on these findings it seems that bilateral RAS does not "mimic" unilateral stenosis in renographic terms, but rather, resembles a normal situation.
Significant renographic changes can occur at 30% of arterial luminal narrowing in renal artery disease.
本研究旨在确定导致肾图参数发生变化的肾动脉狭窄（RAS）程度。
将72例因疑似肾血管性高血压而接受肾血管造影的患者的RAS管腔狭窄的血管造影严重程度与131I - 马尿酸肾图特征进行比较。
当比较狭窄和非狭窄肾脏时，在动脉管腔狭窄30%时，Tmax、T1/2以及至Tmax的曲线下计数存在显著差异。在单侧RAS患者中，在狭窄30%时，双侧肾脏之间Tmax曲线下计数的差异也有显著不同。另一方面，双侧狭窄患者与原发性高血压患者难以很好地区分，因为两侧的Tmax值或两肾之间Tmax的差异以及其他参数的值相似，除了至Tmax的计数差异。基于这些发现，似乎双侧RAS在肾图方面并不“模拟”单侧狭窄，而是类似于正常情况。
肾动脉疾病中动脉管腔狭窄30%时可出现显著的肾图变化。
