Johnson L N, Krohel G B, Allen S D, Mozayeni R
Neuro-Ophthalmology Unit, Mason Institute of Ophthalmology, University of Missouri-Columbia 65212, USA.
J Natl Med Assoc. 1996 Jun;88(6):369-73.
This case-control study was undertaken to determine if recurrent herpes labialis posed an independent risk factor for the development of nonarteritic anterior ischemic optic neuropathy among individuals with small optic nerve cup:disk ratio. The study population was comprised of 43 nonarteritic anterior ischemic optic neuropathy cases and 30 consecutive control subjects with < or = 0.1 optic nerve cup:disk ratio. The two groups were compared with respect to the history of recurrent herpes labialis, cigarette smoking status, hypertension, diabetes mellitus, cardiovascular disease, and cerebrovascular disease. The nonarteritic anterior ischemic optic neuropathy cases were comparable to controls with respect to cigarette smoking status, hypertension, diabetes mellitus, cardiovascular disease, and cerebrovascular disease status. Nonarteritic anterior ischemic optic neuropathy cases were significantly more likely to have a history of recurrent herpes labialis than controls. Herpes simplex virus as identified by recurrent herpes labialis plays a role in the development of nonarteritic anterior ischemic optic neuropathy. However, a casual relationship cannot be established.
本病例对照研究旨在确定在视神经杯盘比小的个体中，复发性唇疱疹是否是非动脉炎性前部缺血性视神经病变发生的独立危险因素。研究人群包括43例非动脉炎性前部缺血性视神经病变患者和30例连续入选的视神经杯盘比≤0.1的对照者。比较两组患者复发性唇疱疹病史、吸烟状况、高血压、糖尿病、心血管疾病和脑血管疾病情况。非动脉炎性前部缺血性视神经病变患者在吸烟状况、高血压、糖尿病、心血管疾病和脑血管疾病方面与对照者相当。非动脉炎性前部缺血性视神经病变患者有复发性唇疱疹病史的可能性显著高于对照者。由复发性唇疱疹所证实的单纯疱疹病毒在非动脉炎性前部缺血性视神经病变的发生中起作用。然而，无法确定因果关系。
