[光化学疗法治疗皮肤急性移植物抗宿主病——一例报告]
[PUVA therapy for cutaneous acute graft-versus-host disease--a case report].
作者信息
Inamitsu T, Inoue M, Akiyoshi H, Honda K, Shibuya T, Nakayama H, Ueda K
机构信息
Division of Pediatrics, Kyushu University, Fukuoka, Japan.
出版信息
Rinsho Ketsueki. 1995 Nov;36(11):1321-5.
We performed 8-methoxypsolaren and ultraviolet A (PUVA) therapy as a second line treatment for stage +3 cutaneous acute graft-versus-host disease (GVHD) in a 10-year-old girl who had undergone unrelated bone marrow transplantation. Although prednisolone as first line therapy was not effective, the cutaneous lesion began to improve after several times of PUVA treatment and completely disappeared following 11 times of irradiation without additive systemic immunosuppressive therapy. PUVA therapy was considered as a useful treatment for cutaneous acute GVHD.
我们对一名接受非亲缘骨髓移植的10岁女孩，采用8-甲氧基补骨脂素联合紫外线A（PUVA）疗法，作为治疗Ⅲ度皮肤急性移植物抗宿主病（GVHD）的二线治疗方案。尽管作为一线治疗的泼尼松龙无效，但在进行几次PUVA治疗后，皮肤病变开始改善，在照射11次后完全消失，且未添加全身性免疫抑制治疗。PUVA疗法被认为是治疗皮肤急性GVHD的一种有效疗法。
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