[采用123I-间碘苄胍心肌单光子发射计算机断层扫描评估接受COP-BLAM和粒细胞集落刺激因子治疗的老年非霍奇金淋巴瘤患者的心脏毒性]
[Assessment of cardiac toxicity by 123I-MIBG myocardial SPECT in elderly non-Hodgkin lymphoma patients treated with COP-BLAM and G-CSF].
作者信息
Niitsu N, Umeda M
机构信息
First Department of Internal Medicine, Toho University School of Medicine, Tokyo, Japan.
出版信息
Rinsho Ketsueki. 1995 Nov;36(11):1326-8.
COP-BLAM chemotherapy with concomitant G-CSF was performed on patients 65 or older with non-Hodgkin's lymphoma (NHL), and cardiac sympathetic disorders due to the chemotherapeutic agents were studied using 123I-MIBG (metaiodobenzylguanidine) myocardial SPECT (single photon emission CT). The results showed no correlation between the ejection fraction due to echocardiography and the total dose of adriamycin (ADR). However, there was a positive correlation between the total dose of ADR and the washout rate, and the possibility of cardiac sympathetic disorders caused by ADR was suggested.
对65岁及以上的非霍奇金淋巴瘤（NHL）患者进行COP-BLAM化疗并同时使用粒细胞集落刺激因子（G-CSF），并使用123I-间碘苄胍（MIBG）心肌单光子发射计算机断层扫描（SPECT）研究化疗药物引起的心脏交感神经紊乱。结果显示，超声心动图测得的射血分数与阿霉素（ADR）总剂量之间无相关性。然而，ADR总剂量与洗脱率之间存在正相关，提示存在ADR引起心脏交感神经紊乱的可能性。
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