Hiyoyama K, Wada H, Shimura M, Deguchi H, Nagaya S, Wakita Y, Deguchi K, Shiku H
2nd Department of Internal Medicine, Mie University School of Medicine, Tsu, Japan.
Rinsho Byori. 1996 Jan;44(1):57-60.
The Plasma level of soluble fibrin monomer (sFM) was measured in 218 patients with a hematopoietic malignancy. Of them, 198 were diagnosed with disseminates intravascular coagulation (DIC), 20 with Pre-DIC, and 20 with Non-DIC. Pre-DIC was retrospectively defined as the condition at least 1 week before the onset of DIC. The plasma levels of sFM, thrombin-anti-thrombin III complex (TAT), plasmin alpha 2-antiplasmin inhibitor complex (PIC), and FDP-D-dimer were significantly higher in patients with DIC than in those with Non-DIC. These levels were significantly higher in patients with Pre-DIC than in those with Non-DIC. Among these hemostatic parameters, the plasma sFM showed the highest sensitivity and specificity for DIC or Pre-DIC. These findings suggests that sFM is the most valuable marker hemostatic for the diagnosis of DIC and Pre-DIC.
对218例血液系统恶性肿瘤患者测定了可溶性纤维蛋白单体（sFM）的血浆水平。其中，198例被诊断为弥散性血管内凝血（DIC），20例为DIC前期（Pre-DIC），20例为非DIC。Pre-DIC被回顾性定义为DIC发病前至少1周的状态。DIC患者的sFM、凝血酶 - 抗凝血酶III复合物（TAT）、纤溶酶α2 - 抗纤溶酶抑制剂复合物（PIC）和FDP - D - 二聚体的血浆水平显著高于非DIC患者。Pre-DIC患者的这些水平显著高于非DIC患者。在这些止血参数中，血浆sFM对DIC或Pre-DIC表现出最高的敏感性和特异性。这些发现表明，sFM是诊断DIC和Pre-DIC最有价值的止血标志物。
