Momoki S, Fukushima I, Hoshi T, Kato S, Kishiro I, Suzuki H, Hase T, Kuga H, Nakamoto T, Iizuka M, Suzuki S, Nagai S, Shimada K
First Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Nihon Kyobu Shikkan Gakkai Zasshi. 1996 Apr;34(4):494-9.
A 50-year-old woman was admitted to our hospital complaining of recurrent bloody sputum and hemoptysis. Chest X-ray films showed an infiltrative shadow in the left lower lung field. Chest computed tomograms showed a nodular tumor shadow near the left B8 and this tumor shadow was found between A8 and A9 by pulmonary arteriography. Bronchoscopic examination revealed a red coagulum in the left B8 and cytologic examination of broncho alveolar lavage fluid revealed atypical squamous cells. With a clinical diagnosis of squamous cell carcinoma of the lung, a left lower lobectomy with hilar and mediastinal lymph node dissection was done. A milk-white tumor was found in the lower lobe of the resected lung. The pathological diagnosis of the resected tissue specimen was carcinoid, accompanied by pulmonary, hilar, and mediastinal lymph node metastases. Reduced immunofluorescence by Chromogranin A and serotonin staining were further evidence that the tumor was atypical. This case is very interesting in that the tumor metastasized to the lung and lymph nodes, even-though it was pathologically typical.
一名50岁女性因反复咯血痰和咯血入院。胸部X线片显示左下肺野有浸润性阴影。胸部计算机断层扫描显示左B8附近有结节状肿瘤阴影,通过肺动脉造影在A8和A9之间发现了该肿瘤阴影。支气管镜检查发现左B8有红色凝血块,支气管肺泡灌洗液体细胞检查发现非典型鳞状细胞。临床诊断为肺鳞状细胞癌,行左下肺叶切除加肺门和纵隔淋巴结清扫术。在切除的肺下叶发现一个乳白色肿瘤。切除组织标本的病理诊断为类癌,伴有肺、肺门和纵隔淋巴结转移。嗜铬粒蛋白A和血清素染色显示免疫荧光减弱,进一步证明该肿瘤是非典型的。该病例非常有趣,因为尽管肿瘤在病理上是典型的,但却转移到了肺和淋巴结。