立氏立克次体190 kDa抗原基因重复区域的缺失
Deletion in the 190 kDa antigen gene repeat region of Rickettsia rickettsii.
作者信息
Matsumoto M, Tange Y, Okada T, Inoue Y, Horiuchi T, Kobayashi Y, Fujita S
机构信息
First Department of Internal Medicine, School of Medicine, Ehime University, Japan.
出版信息
Microb Pathog. 1996 Jan;20(1):57-62. doi: 10.1006/mpat.1996.0005.
The 190 kDa outer membrane protein of Rickettsia rickettsii is a major immunodominant protective antigen which contains 13 tandem nearly identical repeating sequences. We have identified a deletion in the 190 kDa antigen gene of R. rickettsii strain Smith maintained in the laboratory. The deletion occurred within the repeat region of this gene and the mutated repeat region corresponded to one repeating unit in size.
立氏立克次氏体的190 kDa外膜蛋白是一种主要的免疫显性保护性抗原，它含有13个串联的几乎相同的重复序列。我们已经在实验室保存的立氏立克次氏体史密斯菌株的190 kDa抗原基因中鉴定出一个缺失。该缺失发生在该基因的重复区域内，突变的重复区域在大小上相当于一个重复单元。
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