Mahieu H F, Kooper D P, Leemans C R
Academisch Ziekenhuis Vrije Universiteit, afd. Keel-, Neus- en Oorheelkunde, Amsterdam.
Ned Tijdschr Geneeskd. 1996 Apr 20;140(16):886-90.
To evaluate endoscopic CO2 laser vaporization as a treatment of small glottic laryngeal carcinomas selected by means of video laryngo-stroboscopy.
Prospective.
ENT department, University hospital, Free University Amsterdam.
Patients with a small glottic laryngeal carcinoma (stage Tis or T1a), were selected by means of video-laryngo-stroboscopy for a single stage endoscopic CO2 laser vaporization treatment as an alternative for radiotherapy. They were followed up for at least 24 months.
Three of the 46 patients (6%) developed a local recurrence within 2 years; one of these could be treated once more with the CO2 laser, the other two were irradiated. None of these patients developed metastases in cervical lymph nodes or distant metastases. Most patients (41, 89%) assessed their voices after CO2 laser vaporization as normal or almost normal. Slight dysphonia was reported by five patients (11%). No serious dysphonia or aphonia occurred.
Endoscopic CO2 laser vaporization, compared with radiotherapy or more extensive surgery, constitutes an adequate treatment for selected patients with small glottic laryngeal carcinomas. As a result of this treatment, it will be possible to preserve the larynx in more patients.
评估经视频喉镜频闪检查筛选的小声门型喉癌患者行内镜下二氧化碳激光汽化术的治疗效果。
前瞻性研究。
阿姆斯特丹自由大学大学医院耳鼻喉科。
通过视频喉镜频闪检查筛选出小声门型喉癌（Tis期或T1a期）患者，采用单阶段内镜下二氧化碳激光汽化术作为放射治疗的替代方案。对患者进行至少24个月的随访。
46例患者中有3例（6%）在2年内出现局部复发；其中1例可再次接受二氧化碳激光治疗，另外2例接受放疗。这些患者均未出现颈部淋巴结转移或远处转移。大多数患者（41例，89%）在二氧化碳激光汽化术后评估其声音正常或几乎正常。5例患者（11%）报告有轻微发音障碍。未出现严重发音障碍或失音。
与放射治疗或更广泛的手术相比，内镜下二氧化碳激光汽化术是所选小声门型喉癌患者的一种充分治疗方法。通过这种治疗，更多患者的喉部得以保留。
