Sklar G S, Lanks K W
Anesthesiology. 1977 Jul;47(1):31-33. doi: 10.1097/00000542-197707000-00007.
The use of hypotensive agents in combination with succinylcholine may be necessary. Since trimethaphan has been reported to prolong the action of succinylcholine, the authors studied the abilities of trimethaphan and sodium nitroprusside to inhibit hydrolysis of succinylcholine by pseudocholinesterase in vitro. Trimethaphan was found to be a potent noncompetitive inhibitor of pseudocholinesterase (KI = 0.24 micronM). It could be calculated that a typical dose of trimethaphan would approximately double the duration of paralysis produced by the usual dose of succinylcholine. Nitroprusside had no inhibitory effect in vitro. It is concluded that nitroprusside is preferable when a hypotensive agent must be used in conjunction with succinylcholine.
可能有必要将降压药与琥珀酰胆碱联合使用。由于已报道三甲噻方可延长琥珀酰胆碱的作用时间，因此作者研究了三甲噻方和硝普钠在体外抑制假性胆碱酯酶水解琥珀酰胆碱的能力。发现三甲噻方是假性胆碱酯酶的一种强效非竞争性抑制剂（抑制常数KI = 0.24微摩尔）。可以计算出，典型剂量的三甲噻方可使常用剂量的琥珀酰胆碱所致麻痹的持续时间延长约一倍。硝普钠在体外无抑制作用。结论是，当必须将降压药与琥珀酰胆碱联合使用时，硝普钠更为可取。
