Vattimo A, Burroni L, Bertelli P, Volterrani D, Vella A
Department of Nuclear Medicine, Policlinico Le Scotte, University of Siena, Italy.
Nucl Med Commun. 1996 Jan;17(1):48-53. doi: 10.1097/00006231-199601000-00009.
We performed 99Tcm-ethyl cysteinate dimer (ECD) interictal single photon emission tomography (SPET) in 26 children with severe therapy-resistant epilepsy. All the children underwent a detailed clinical examination, an electroencephalogram (EEG) investigation and brain magnetic resonance imaging (MRI). In 21 of the 26 children, SPET demonstrated brain blood flow abnormalities, in 13 cases in the same territories that showed EEG alterations. MRI showed structural lesions in 6 of the 26 children, while SPET imaging confirmed these abnormalities in only 5 children. The lesion not detected on SPET was shown to be 3 mm thick on MRI. Five symptomatic patients had normal SPET. In one of these patients, the EEG findings were normal and MRI revealed a small calcific nodule (4 mm thick); in the others, the EEG showed non-focal but diffuse abnormalities. These data confirm that brain SPET is sensitive in detecting and localizing hypoperfused areas that could be associated with epileptic foci in this group of patients, even when the MRI image is normal.
我们对26名患有严重难治性癫痫的儿童进行了99锝-乙半胱氨酸二聚体（ECD）发作间期单光子发射断层扫描（SPET）。所有儿童均接受了详细的临床检查、脑电图（EEG）检查和脑磁共振成像（MRI）。在26名儿童中的21名中，SPET显示脑血流异常，其中13例在脑电图显示改变的相同区域。MRI显示26名儿童中有6名存在结构性病变，而SPET成像仅在5名儿童中证实了这些异常。SPET未检测到的病变在MRI上显示为3毫米厚。5名症状性患者的SPET结果正常。其中1例患者的脑电图结果正常，MRI显示一个小钙化结节（4毫米厚）；其他患者的脑电图显示非局灶性但弥漫性异常。这些数据证实，即使MRI图像正常，脑SPET在检测和定位可能与该组患者癫痫灶相关的灌注不足区域方面也很敏感。
