蒲公英甾烷型三萜对12-氧-十四烷酰佛波醇-13-乙酸酯在小鼠皮肤两阶段致癌过程中肿瘤促进作用的抑制效果。
Inhibitory effect of taraxastane-type triterpenes on tumor promotion by 12-O-tetradecanoylphorbol-13-acetate in two-stage carcinogenesis in mouse skin.
作者信息
Yasukawa K, Akihisa T, Oinuma H, Kaminaga T, Kanno H, Kasahara Y, Tamura T, Kumaki K, Yamanouchi S, Takido M
机构信息
College of Pharmacy, Nihon University, Chiba, Japan.
出版信息
Oncology. 1996 Jul-Aug;53(4):341-4. doi: 10.1159/000227584.
Two taraxastane-type hydroxy triterpenes, taraxasterol and faradiol, isolated from the flowers of Compositae plants Cynara scolymus (artichoke) and Chrysanthemum morifilolium (chrysanthemum), respectively, showed strong inhibitory activity against 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced inflammation in mice. At 2.0 mumol/mouse, these compounds inhibited markedly the tumor-promoting effect of TPA (1 microgram/mouse) on skin tumor formation following initiation with 7,12-dimethylbenz[alpha]anthracene (50 micrograms/mouse).
从菊科植物洋蓟（Cynara scolymus）和菊花（Chrysanthemum morifilolium）的花朵中分别分离出的两种蒲公英甾烷型羟基三萜类化合物，蒲公英甾醇和法呢二醇，对12 - O - 十四酰佛波醇 - 13 - 乙酸酯（TPA）诱导的小鼠炎症表现出强烈的抑制活性。在2.0 μmol/小鼠的剂量下，这些化合物显著抑制了TPA（1 μg/小鼠）对7,12 - 二甲基苯并[α]蒽（50 μg/小鼠）引发后皮肤肿瘤形成的促肿瘤作用。
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