Skarpetowski A C, Pawłowska J, Madaliński K
Dział Immunologii Klinicznej Centrum Zdrowia Dziecka w Warszawie.
Pediatr Pol. 1995 May;70(5):413-25.
The authors discuss some of the aspects of chronic hepatitis C infection e.g. interferon alpha treatment. They describe the current state of knowledge on HCV pathophysiology: liver pathology, immunological phenomena, autoimmunity. Attention is paused on development of hepatitis C serodiagnosis which enables patient monitoring during infection and therapy: detection of serum anti-HCV antibodies with third and fourth generation ELISA kits; the polymerase chain reaction (PCR), which enables detection of viral nucleic acid (HCV-RNA). Some differences in interferon therapy in children are also described.
作者们讨论了慢性丙型肝炎感染的一些方面，例如干扰素α治疗。他们描述了目前关于丙型肝炎病毒病理生理学的知识现状：肝脏病理学、免疫现象、自身免疫。重点关注丙型肝炎血清学诊断的发展，这有助于在感染和治疗期间对患者进行监测：使用第三代和第四代酶联免疫吸附测定试剂盒检测血清抗丙型肝炎病毒抗体；聚合酶链反应（PCR），可检测病毒核酸（丙型肝炎病毒核糖核酸）。还描述了儿童干扰素治疗中的一些差异。
