Chen J, Chang S, Duncan S A, Okano H J, Fishell G, Aderem A
The Rockefeller University, New York, NY 10021, USA.
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6275-9. doi: 10.1073/pnas.93.13.6275.
MacMARCKS is a member of the MARCKS family of protein kinase C (PKC) substrates. Biochemical evidence demonstrates that these proteins integrate calcium and PKC-dependent signals to regulate actin structure at the membrane. We report here that deletion of the MacMARCKS gene prevents cranial neural tube closure in the developing brain, resulting in anencephaly. This suggests a central role for MacMARCKS and the PKC signal transduction pathway in the folding of the anterior neural plate during the early phases of brain formation, and supports the hypothesis that actin-based motility directs cranial neural tube closure.
MacMARCKS是蛋白激酶C（PKC）底物的MARCKS家族成员。生化证据表明，这些蛋白质整合钙和PKC依赖信号，以调节细胞膜处的肌动蛋白结构。我们在此报告，MacMARCKS基因的缺失会阻止发育中大脑的颅神经管闭合，导致无脑畸形。这表明MacMARCKS和PKC信号转导通路在脑形成早期阶段前神经板的折叠过程中起核心作用，并支持基于肌动蛋白的运动引导颅神经管闭合这一假说。
