乙型肝炎病毒感染的动态变化
The dynamics of hepatitis B virus infection.
作者信息
Payne R J, Nowak M A, Blumberg B S
机构信息
Department of Zoology, University of Oxford, United Kingdom.
出版信息
Proc Natl Acad Sci U S A. 1996 Jun 25;93(13):6542-6. doi: 10.1073/pnas.93.13.6542.
Abstract
We consider a cellular model of infection by the hepatitis B virus and describe how it may be used to account for two important features of the disease, namely (i) the wide variety of manifestations of infection and the age dependence thereof, and (ii) the typically long delay before the development of virus-induced liver cancer (primary hepatocellular carcinoma). The model is based on the assumption that the liver is comprised of both immature and mature hepatocytes, with these two subpopulations of cells responding contrastingly upon infection by the virus.
摘要
我们考虑了乙型肝炎病毒感染的细胞模型，并描述了该模型如何用于解释该疾病的两个重要特征，即：（i）感染表现形式的多样性及其与年龄的相关性，以及（ii）病毒诱发的肝癌（原发性肝细胞癌）发生前通常存在的较长潜伏期。该模型基于这样的假设：肝脏由未成熟和成熟的肝细胞组成，这两类细胞亚群在受到病毒感染时会产生截然不同的反应。
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本文引用的文献
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