Exner G U, von Hochstetter A R, Schreiber A, Sokolovic-Dalipagic E
Balgrist, Orthopädische Universitätsklinik, Zürich.
Praxis (Bern 1994). 1996 May 28;85(22):706-13.
At the Balgrist hospital 38 patients with osteosarcoma and 18 patients with Ewing sarcoma were treated from 1970 through 1992; a follow-up of at least three years is available for all patients. Disease-free survival in this period of time has increased from 20% (Ewing sarcoma) and 30% (osteosarcoma) to over 75%. While systemic tumor control was improved by systematic chemotherapy, local tumor control was improved by appropriate biopsy techniques, and amputations have been replaced by local resections, in most cases with reconstruction (arthrodesis, rotation plasty, endoprosthesis, allografts), which require further improvements. With respect to cure of the neoplastic disease, the currently available methods have been used to their maximum potential, and a steady state has been reached regarding survival. Further improvement of survival will therefore depend on the introduction of completely new modalities.
1970年至1992年期间，巴尔格里斯特医院共治疗了38例骨肉瘤患者和18例尤因肉瘤患者；所有患者均有至少三年的随访记录。在此期间，无病生存率从20%（尤因肉瘤）和30%（骨肉瘤）提高到了75%以上。虽然系统性化疗改善了全身肿瘤控制，适当的活检技术改善了局部肿瘤控制，截肢术已被局部切除术取代，大多数情况下还进行了重建（关节固定术、旋转成形术、内置假体、同种异体移植）——这些仍需进一步改进。就肿瘤疾病的治愈而言，目前可用的方法已发挥到最大潜力，在生存率方面已达到稳定状态。因此，生存率的进一步提高将取决于全新治疗方式的引入。
