通过受污染的静脉注射免疫球蛋白感染丙型肝炎病毒：法国一项全国性前瞻性调查的结果。
Infection by hepatitis C virus through contaminated intravenous immune globulin: results of a prospective national inquiry in France.
作者信息
Lefrère J J, Loiseau P, Martinot-Peignoux M, Mariotti M, Ravera N, Thauvin M, Marcellin P, Janot C
机构信息
Institut National de Transfusion Sanguine, Hôpital Saint-Louis, Paris, France.
出版信息
Transfusion. 1996 May;36(5):394-7. doi: 10.1046/j.1537-2995.1996.36596282581.x.
BACKGROUND
A recent hepatitis C virus (HCV) outbreak has been suspected of being caused by an infusion of intravenous immune globulin.
STUDY DESIGN AND METHODS
Three laboratories were mandated by the French regulatory agency to prospectively screen on a national scale those persons having received suspected batches: 233 exposed patients were recalled and tested for HCV antibody and for HCV RNA.
RESULTS
Nineteen patients (8.1%) were found positive for HCV RNA; 7 of these 19 were positive for the HCV antibody.
CONCLUSION
The link between HCV infection and intravenous immune globulin was reinforced by the overrepresentation of the 2b genotype (58%), which contrasts with the low prevalence of this genotype in France (1%).
背景
近期怀疑一起丙型肝炎病毒（HCV）暴发是由静脉注射免疫球蛋白输注所致。
研究设计与方法
法国监管机构指定三个实验室在全国范围内对接受过可疑批次药物的人员进行前瞻性筛查：召回233名暴露患者并检测HCV抗体和HCV RNA。
结果
19名患者（8.1%）HCV RNA检测呈阳性；这19名患者中有7名HCV抗体检测呈阳性。
结论
2b基因型（58%）的过度出现进一步证实了HCV感染与静脉注射免疫球蛋白之间的联系，这与该基因型在法国的低流行率（1%）形成对比。
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