Nakahara K, Iso A, Chao C R, Cooper T B, Morishima H O
Department of Anesthesiology, College of Physicians and Surgeons, Columbia University, New York, NY, USA.
Am J Obstet Gynecol. 1996 Jul;175(1):188-93. doi: 10.1016/s0002-9378(96)70273-9.
Our purpose was to test whether cocaine stimulates uterine activity in nonpregnant and pregnant rats.
The carotid artery and jugular vein were chronically catheterized, and a microballoon probe was inserted into the uterine cavity of 15 pregnant and 14 nonpregnant female rats. Conscious animals received a bolus dose of either cocaine or saline solution intravenously. Cardiovascular and uterine contractile responses were studied.
Cocaine (2.5 mg/kg) induced a marked increase in uterine activity and arterial blood pressure in both pregnant and nonpregnant animals without producing systemic toxicity. The maximum change in uterine contractions was greater in the pregnant group than in the nonpregnant group, and blood pressure responses were transient in both.
This study is the first demonstration that cocaine stimulates the rat uterus in vivo, with a greater increase in contractions in pregnant compared with nonpregnant animals. These differences are not related to the hemodynamic response or pharmacokinetic profile of cocaine.
我们的目的是测试可卡因是否会刺激未怀孕和怀孕大鼠的子宫活动。
对15只怀孕和14只未怀孕的雌性大鼠进行颈动脉和颈静脉长期插管，并将微球囊探头插入子宫腔。清醒的动物静脉注射一剂可卡因或生理盐水溶液。研究心血管和子宫收缩反应。
可卡因（2.5毫克/千克）在怀孕和未怀孕的动物中均引起子宫活动和动脉血压显著升高，且未产生全身毒性。怀孕组子宫收缩的最大变化大于未怀孕组，两组的血压反应均为短暂性。
本研究首次证明可卡因在体内刺激大鼠子宫，与未怀孕动物相比，怀孕动物的收缩增加幅度更大。这些差异与可卡因的血流动力学反应或药代动力学特征无关。
