de Groot C J, O'Brien T J, Taylor R N
Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco 94143-0132, USA.
Am J Obstet Gynecol. 1996 Jul;175(1):24-9. doi: 10.1016/s0002-9378(96)70245-4.
Reduced trophoblastic migration into the decidua during the first half of pregnancy is a fundamental abnormality in preeclampsia. CA 125 and insulin-like growth factor binding protein-1 are major endometrial proteins whose primary sources are decidual epithelial and stromal cells, respectively. We hypothesized that reduced trophoblastic invasion in pregnancies destined for preeclampsia would affect the maternal vascular deportation of these decidual proteins.
CA 125 and insulin-like growth factor binding protein-1 concentrations were analyzed by radioimmunoassays of plasma from preeclamptic and matched control patients in a longitudinal, nested case-control study.
CA 125 concentrations did not differ with respect to pregnancy outcome or trimester. Midtrimester plasma insulin-like growth factor binding protein-1 concentrations were significantly lower in women who later had preeclampsia compared with normal pregnant controls.
These findings provide biochemical evidence that abnormalities of trophoblastic invasion affect the maternal vascular deportation of a decidual stromal protein. Lower circulating concentrations of insulin-like growth factor binding protein-1 in women destined to have preeclampsia were observed 12 to 26 weeks before the onset of clinical signs of this syndrome.
妊娠前半期滋养层细胞向蜕膜迁移减少是先兆子痫的一个基本异常情况。CA 125和胰岛素样生长因子结合蛋白-1是主要的子宫内膜蛋白，其主要来源分别是蜕膜上皮细胞和基质细胞。我们推测，先兆子痫妊娠中滋养层细胞侵袭减少会影响这些蜕膜蛋白的母体血管转运。
在一项纵向嵌套病例对照研究中，通过放射免疫分析法对先兆子痫患者和匹配的对照患者血浆中的CA 125和胰岛素样生长因子结合蛋白-1浓度进行分析。
CA 125浓度在妊娠结局或孕期方面没有差异。与正常妊娠对照组相比，孕中期血浆胰岛素样生长因子结合蛋白-1浓度在后来发生先兆子痫的女性中显著降低。
这些发现提供了生化证据，表明滋养层细胞侵袭异常会影响蜕膜基质蛋白的母体血管转运。在该综合征临床症状出现前12至26周，观察到先兆子痫女性循环中胰岛素样生长因子结合蛋白-1浓度较低。
