van Dalen A
Department of Nuclear Medicine, Groene Hart Ziekenhuis, Gouda, The Netherlands.
Anticancer Res. 1996 Jul-Aug;16(4B):2345-9.
Tissue polypeptide antigen has been advocated over the past two decades as a serum tumour marker. It was a long time before it was proven that these proteins in the serum are related to cytokeratin fragments. In this study the different behaviour of the test systems TPA, TPS, TPA(cyk) and CYFRA 21.1 were investigated in serum samples, mainly of metastasized cancer patients. By selecting individual samples with a high and a low TPA/TPS ratio it could be proven that no correlation existed in these samples between TPS (determining fragments of cytokeratin 18) and CYFRA 21.1 (determining fragments of cytokeratin 19). On the contrary, a good correlation was established between the TPA test and the CYFRA 21.1 test, and intermediate correlations were present between these tests and TPA (cyk). The TPA (cyk) test determines cytokeratin 8 and 18 fragments. During therapy, monitoring of metastasized patients with these tests could show a different pattern of reactivity. It is concluded that the different test results during therapy monitoring are not always easy to interpretate. The release of cytokeratins from cancer cells needs further study.
在过去二十年里，组织多肽抗原一直被推崇为一种血清肿瘤标志物。过了很长时间才证实血清中的这些蛋白质与细胞角蛋白片段有关。在本研究中，主要对转移性癌症患者的血清样本，研究了TPA、TPS、TPA(cyk)和CYFRA 21.1检测系统的不同表现。通过选择TPA/TPS比值高和低的个体样本，可以证明在这些样本中，TPS（检测细胞角蛋白18片段）和CYFRA 21.1（检测细胞角蛋白19片段）之间不存在相关性。相反，TPA检测和CYFRA 21.1检测之间建立了良好的相关性，并且这些检测与TPA(cyk)之间存在中等程度的相关性。TPA(cyk)检测可测定细胞角蛋白8和18片段。在治疗期间，用这些检测对转移性患者进行监测可能会显示出不同的反应模式。得出的结论是，治疗监测期间不同的检测结果并不总是容易解释的。癌细胞中细胞角蛋白的释放需要进一步研究。
