Meunier B, Spiliopoulos Y, Stasik C, Lakéhal M, Malledant Y, Launois B
Department of Digestive Surgery, Centre Hospitalier, Rennes, France.
Ann Thorac Surg. 1996 Aug;62(2):373-7.
A palliative bypass operation may be beneficial when severe dysphagia or tracheoesophageal fistula occurs after radiochemotherapy for unresectable tumor of the esophagus.
Thirty-two patients with an unresectable tumor of the esophagus underwent a palliative retrosternal gastric (29) or colonic (3) bypass operation with ligature of the lower esophagus (3) or drainage (27). Tracheoesophageal fistula was present at operation in 20 (62.5%), including 8 after radiochemotherapy.
The overall operative mortality rate was 34.4%: 45% with tracheoesophageal fistula and 16.6% without (p < 0.01). Median intensive care and hospitalization times were 5 and 19 days, respectively. Median postoperative survival was 6 months (range, 53 to 492 days). Complications in 21 survivors were lung infections (seven), cervical fistulas (eight), and failure of the esophageal suture (two); 19 patients resumed oral nutrition, and quality of life was excellent in 6. All eight cervical fistulas regressed favorably. Postoperative radiotherapy or chemotherapy did not improve survival.
Despite the high operative mortality rate, bypass operation can provide good palliation and allow subsequent radiochemotherapy in selected patients with an unresectable tumor of the esophagus.
对于无法切除的食管肿瘤患者,在放化疗后出现严重吞咽困难或气管食管瘘时,姑息性旁路手术可能有益。
32例无法切除食管肿瘤的患者接受了胸骨后胃旁路手术(29例)或结肠旁路手术(3例),同时对食管下段进行结扎(3例)或引流(27例)。手术时存在气管食管瘘的患者有20例(62.5%),其中8例为放化疗后出现。
总体手术死亡率为34.4%:有气管食管瘘的患者为45%,无气管食管瘘的患者为16.6%(p<0.01)。重症监护和住院时间的中位数分别为5天和19天。术后生存时间的中位数为6个月(范围为53至492天)。21例幸存者的并发症包括肺部感染(7例)、颈部瘘(8例)和食管缝合失败(2例);19例患者恢复经口营养,6例患者生活质量良好。所有8例颈部瘘均顺利愈合。术后放疗或化疗并未改善生存率。
尽管手术死亡率较高,但旁路手术可为部分无法切除食管肿瘤的患者提供良好的姑息治疗,并允许后续进行放化疗。