Ward A C, Csar X F, Hoffmann B W, Hamilton J A
Department of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, Victoria, Australia.
Biochem Biophys Res Commun. 1996 Jul 5;224(1):10-6. doi: 10.1006/bbrc.1996.0976.
The addition of cAMP inhibits G-CSF-mediated proliferation and suppresses pRB phosphorylation in NFS-60 cells. We show that the latter could be attributed to different effects of cAMP in these cells: (i) down-regulation of the levels of cyclins D2 and D3, and cdk4, and (ii) induction of the p27Kip1 inhibitor of cdk4.
添加环磷酸腺苷（cAMP）可抑制粒细胞集落刺激因子（G-CSF）介导的增殖，并抑制NFS-60细胞中视网膜母细胞瘤蛋白（pRB）的磷酸化。我们发现，后者可归因于cAMP在这些细胞中的不同作用：（i）细胞周期蛋白D2和D3以及细胞周期蛋白依赖性激酶4（cdk4）水平的下调，以及（ii）细胞周期蛋白依赖性激酶4的p27Kip1抑制剂的诱导。
