Igakura T, Kadomatsu K, Taguchi O, Muramatsu H, Kaname T, Miyauchi T, Yamamura K, Arimura K, Muramatsu T
Department of Biochemistry, Nagoya University School of Medicine, Japan.
Biochem Biophys Res Commun. 1996 Jul 5;224(1):33-6. doi: 10.1006/bbrc.1996.0980.
Basigin is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. Using the knockout mouse lacking the basigin gene (Bsg), we analyzed the function of basigin in adult mice lacking the gene [Bsg (-1-)]. Although histochemical studies on the localization of basigin (also called HT7 and neurothelin) strongly indicated that it is involved in the function of the blood-brain barrier, basigin knockout mice showed only a little difference, if any, to wild-type mice in the function of the blood brain-barrier. The mitogenic response of lymphocytes upon mixed lymphocyte reaction was greater in Bsg (-1-) mice. Finally, Bsg (-1-) mice repeatedly visited filter paper impregnated with acetic acid or isozine, indicating an abnormality in either reception of the odor or behavior as to it.
基底膜蛋白是一种属于免疫球蛋白超家族的跨膜糖蛋白。我们利用缺乏基底膜蛋白基因（Bsg）的基因敲除小鼠，分析了基底膜蛋白在缺乏该基因的成年小鼠[Bsg（-/-）]中的功能。尽管对基底膜蛋白（也称为HT7和神经腱蛋白）定位的组织化学研究强烈表明它参与血脑屏障的功能，但基底膜蛋白基因敲除小鼠在血脑屏障功能方面与野生型小鼠相比，即使有差异也很小。在混合淋巴细胞反应中，Bsg（-/-）小鼠淋巴细胞的促有丝分裂反应更强。最后，Bsg（-/-）小鼠会反复靠近浸有醋酸或异嗪的滤纸，这表明它们在气味感知或对气味的行为方面存在异常。
