Kusumi I, Ishikane T, Matsubara S, Koyama T
Department of Psychiatry, Hokkaido University School of Medicine, Sapporo, Japan.
J Neural Transm Gen Sect. 1995;101(1-3):231-5. doi: 10.1007/BF01271560.
We examined the effects of long-term treatment with haloperidol and clozapine on dopamine D4 receptors in rat frontal cortex. Dopamine D4 receptor binding sites were indirectly determined from the displacement experiments of [3H]clozapine binding using nemonapride. Three-weeks administration of haloperidol (0.5 mg/kg) or clozapine (10 mg/kg) did not significantly affect the D4 receptors in the frontal cortex. The density of D2 receptors, determined by [3H]spiperone binding to striatum, was increased by long-term treatment with haloperidol, but it was not significantly changed by that with clozapine.
我们研究了氟哌啶醇和氯氮平长期治疗对大鼠额叶皮质多巴胺D4受体的影响。使用奈莫必利通过[3H]氯氮平结合的置换实验间接测定多巴胺D4受体结合位点。给予氟哌啶醇（0.5mg/kg）或氯氮平（10mg/kg）三周对额叶皮质的D4受体没有显著影响。通过[3H]螺哌隆与纹状体结合测定的D2受体密度，经氟哌啶醇长期治疗后增加，但经氯氮平治疗后无显著变化。
