Martí Massó J F, Poza J J, López de Munain A
Servicio de Neurología, Hospital Nuestra Señora de Aránzazu, San Sebastián.
Neurologia. 1996 Mar;11(3):109-15.
The patient with Parkinson's disease often needs concomitant treatment for disorders that accompany the disease, such as depression, insomnia or constipation, or for frequent concomitant alterations such as dizziness, high blood pressure or heart disease. The many drugs that can worsen motor symptoms in Parkinson's disease must be avoided, especially if use will be prolonged. Not all drugs that induce or aggravate parkinsonism have the same potency. We describe 3 groups: 1) drugs that invariably induce or aggravate parkinsonism if taken long enough or at high enough doses; 2) drugs that only provoke parkinsonism in some individuals, and 3) drugs that interfere with the action of levodopa. Knowledge of these drugs is essential for all doctors who treat patients with Parkinson's disease.
帕金森病患者常常需要针对伴随该疾病出现的病症进行联合治疗,比如抑郁、失眠或便秘,或者针对频繁出现的并发改变,如头晕、高血压或心脏病。必须避免使用许多会加重帕金森病运动症状的药物,尤其是如果要长期使用的话。并非所有诱发或加重帕金森综合征的药物都具有相同的效力。我们描述了3组药物:1)如果服用时间足够长或剂量足够高就一定会诱发或加重帕金森综合征的药物;2)仅在某些个体中引发帕金森综合征的药物;3)干扰左旋多巴作用的药物。对于所有治疗帕金森病患者的医生来说,了解这些药物至关重要。